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For instance, Japan has seen a significant reduction in smoking rates through the introduction of noble safer alternatives. The UK and the USA have also implemented comprehensive smoking cessation programmes that include the use of nicotine replacement therapies and other alternatives

The enactment of the TCA coincided with the introduction of new, reduced-harm productsnamely, e-cigarettes or Electronic Nicotine Delivery Systems (ENDS)that have since transformed the tobacco industry

Macrolide resistance genes were identified in STPs and the occurrence of macrolide phosphotransferase ( mph , K06979) was high in all STPs yet a higher number of sequence hits were found for the GD product (Fig

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